Selenocysteine, soluble liver antigen/liver-pancreas, and autoimmune hepatitis
نویسندگان
چکیده
منابع مشابه
Autoimmune hepatitis-specific antibodies against soluble liver antigen and liver cytosol type 1 in patients with chronic viral hepatitis
BACKGROUND Non-organ specific autoantibodies are highly prevalent in patients with chronic hepatitis C (HCV). Among them, anti-liver kidney microsomal type 1 (LKM1) antibody--the serological marker of type 2 autoimmune hepatitis (AIH-2)--is detected in up to 11% of the HCV-infected subjects. On the other hand, anti-liver cytosol type 1 antibodies (anti-LC1)--either in association with anti-LKM1...
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Autoimmune hepatitis is (AIH) is a chronic hepatitis that occurs in children and adults of all ages. It is characterized by immunologic and autoimmune features, including circulating auto antibodies and high serum globulin concentrations. It was first described in the 1950s by term of chronic active hepatitis. It has 2 types with different auto antibodies. Diagnosis is based upon serologic and ...
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BACKGROUND Antinuclear antibodies (ANA), smooth muscle antibodies (SMA) and antibodies to a soluble liver antigen/liver pancreas (anti-SLA/LP) are useful markers that can help clinicians to diagnose and classify autoimmune hepatitis (AIH). OBJECTIVES To determine whether ANA, SMA and anti-SLA/LP help to accurately diagnose patients with AIH. SEARCH STRATEGY The PubMed, CNKI, WANFANG, and Si...
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Autoimmune hepatitis (AIH) is a progressive, chronic inflammatory liver disease of unknown etiology that occurs in children and adults with a prevalence of female. This clinical syndrome is caused by an immune response that is misdirected against self or foreign antigens that resemble self-antigens, leading to a progressive inflammatory and fibrotic process of the liver (Krawitt, 2006; Czaja, 2...
متن کاملAntibodies to soluble liver antigen and α-enolase in patients with autoimmune hepatitis
BACKGROUND: Antibodies to a cytosolic soluble liver antigen (SLA) are specifically detected in patients with autoimmune hepatitis (AIH). The target of anti-SLA has been identified as a ~50 kDa UGA serine tRNA-associated protein complex (tRNP(Ser)Sec), through the screening of cDNA libraries. A recent report questioned the identity of tRNP(Ser)Sec as the real SLA antigen. The latter study identi...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2007
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.21807